Analysis and control of dual-output LCLC resonant converters with significant leakage inductance

The analysis, design and control of fourth-order LCLC voltage-output series-parallel resonant converters for the provision of multiple regulated outputs, is described. Specifically, state-variable concepts are developed to establish operating mode boundaries with which to describe the internal behavior and the impact of output leakage inductance. The resulting models are compared with those obtained from SPICE simulations and measurements from a prototype power supply under closed loop control to verify the analysis, modeling, and control predictions

Analiza dizajna LCLC rezonantnog invertera za dvostupanjsko dvofazno napajanje

This paper deals with the design analysis and synthesis of power resonant inverter with sinusoidal output voltage for sensitive loads. The proposed filter must be capable of removing higher harmonic components from the supplying voltage to reach a harmonic distortion of roughly 5% in the whole range of the load (0 − 100%). The inverter can be supplied from either single-phase voltage inverter in full- or half- bridge connection, or from simple DC/DC buck converter. Non-symmetrical control causes higher harmonic content, both odd and even. Simulation and experimental results based on designed parameters and subsequently obtained from Matlab and OrCad models confirm good quality of output quantities, voltage and current.Tema je ovog članka analiza dizajna i sinteza učinskog rezonantnog invertera sa sinisuidalnim izlaznim naponom za osjetljive terete. Predloženi filtar mora moći filtrirati više harmonike ulaznog napona kako bi distorzija harmonika bila oko 5% u čitavom radnom području (0−100%). Inverter se može napajati ili iz jednofaznog naponskog invertera u mosnom ili uzrokuje pojavu viših harmonika u signalu, kako parnih tako i neparnih. Simulacijski i eksperimentalni rezultati temeljeni na sintetiziranim parametrima dobivenim od modela napravljenih u programskim paketima Matlab i OrCad potvr.uju dobru kvalitetu izlaznih veličina napona i struje

Meta-analysis identifies seven susceptibility loci involved in the atopic march.

Eczema often precedes the development of asthma in a disease course called the 'atopic march'. To unravel the genes underlying this characteristic pattern of allergic disease, we conduct a multi-stage genome-wide association study on infantile eczema followed by childhood asthma in 12 populations including 2,428 cases and 17,034 controls. Here we report two novel loci specific for the combined eczema plus asthma phenotype, which are associated with allergic disease for the first time; rs9357733 located in EFHC1 on chromosome 6p12.3 (OR 1.27; P=2.1 × 10(-8)) and rs993226 between TMTC2 and SLC6A15 on chromosome 12q21.3 (OR 1.58; P=5.3 × 10(-9)). Additional susceptibility loci identified at genome-wide significance are FLG (1q21.3), IL4/KIF3A (5q31.1), AP5B1/OVOL1 (11q13.1), C11orf30/LRRC32 (11q13.5) and IKZF3 (17q21). We show that predominantly eczema loci increase the risk for the atopic march. Our findings suggest that eczema may play an important role in the development of asthma after eczema

Physicians' guideline adherence is associated with long-term heart failure mortality in outpatients with heart failure with reduced ejection fraction: the QUALIFY international registry

Background: Physicians' adherence to guideline-recommended therapy is associated with short-term clinical outcomes in heart failure (HF) with reduced ejection fraction (HFrEF). However, its impact on longer-term outcomes is poorly documented. Here, we present results from the 18-month follow-up of the QUALIFY registry. Methods and results: Data at 18 months were available for 6118 ambulatory HFrEF patients from this international prospective observational survey. Adherence was measured as a continuous variable, ranging from 0 to 1, and was assessed for five classes of recommended HF medications and dosages. Most deaths were cardiovascular (CV) (228/394) and HF-related (191/394) and the same was true for unplanned hospitalizations (1175 CV and 861 HF-related hospitalizations, out of a total of 1541). According to univariable analysis, CV and HF deaths were significantly associated with physician adherence to guidelines. In multivariable analysis, HF death was associated with adherence level [subdistribution hazard ratio (SHR) 0.93, 95% confidence interval (CI) 0.87–0.99 per 0.1 unit adherence level increase; P = 0.034] as was composite of HF hospitalization or CV death (SHR 0.97, 95% CI 0.94–0.99 per 0.1 unit adherence level increase; P = 0.043), whereas unplanned all-cause, CV or HF hospitalizations were not (all-cause: SHR 0.99, 95% CI 0.9–1.02; CV: SHR 0.98, 95% CI 0.96–1.01; and HF: SHR 0.99, 95% CI 0.96–1.02 per 0.1 unit change in adherence score; P = 0.52, P = 0.2, and P = 0.4, respectively). Conclusion: These results suggest that physicians' adherence to guideline-recommended HF therapies is associated with improved outcomes in HFrEF. Practical strategies should be established to improve physicians' adherence to guidelines. © 2019 The Authors. European Journal of Heart Failure © 2019 European Society of Cardiolog